headshot of Ahmed Ali

Ahmed M.
Abdel-Megied Ali

Assistant Professor
School of Pharmacy
Bunting Hall (BUN) 203
aali@ndm.edu
410-532-5043
Programs I teach...

Education 

  • Ph.D. in Pharmacy, Pharmaceutical Analytical Chemistry- Minia University, College of Pharmacy, Egypt, in collaboration with Institute of Medicinal and Pharmaceutical Chemistry, University of Marburg, Germany, 2013. 
  • M.Sc. in Pharmacy, Pharmaceutical Analytical Chemistry- Minia University, College of Pharmacy, Egypt, 2009. 
  • B.S. Pharmacy, Minia University, College of Pharmacy, Egypt, 2003. 

Postdoctoral Associate 

Mass Spectrometry Center, Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, USA.  

Project: Rapid and Comprehensive Detection of SARS-CoV-2 Virus Envelope Lipids. 

Advisor: Prof. Jace W. Jones. 

Postdoctoral Research Fellow 

Pacific University Oregon, School of Pharmacy, Hillsboro, Oregon, USA. 

Project:  Modulation of Arachidonic Acid Metabolism as a new target for the Treatment       of Hypertension through high sensitivity LC-MS/MS bioanalytical method. 

Advisor: Prof. Fawzy. Elbarbry. 

Postdoctoral Research Fellow 

Institute of Medicinal and Pharmaceutical Chemistry, Technical University Braunschweig, (TUB), Braunschweig, Germany. 

Project:  A binding affinity study for simultaneous determination of total and unbound deferiprone- Iron (III) complex using LC-ESI/MS and capillary electrophoresis/frontal analysis (CE/FA) methods. 

Advisor: Prof. Hermann Wätzig and Prof. Sami El- Deeb. 

Research Interests 

  • Drug Pharmacokinetics: Development new methods of analysis for determination of drugs either in pharmaceutical dosage forms or biological fluids using different separation techniques such as Capillary Electrophoresis (CE), HPLC, UPLC and HPTLC couples with different detectors such as PDA, fluorescence and mass spectrometry. 
  • Lipidomics and Metabolomics: Develop mass spectrometry-based platforms that couple biomarker discovery to quantitative validation via the use of chromatography, ion mobility, and mass spectrometry to structurally elucidate and quantify biologically active lipids to further understand disease/injury mechanism of action and provide novel insight for drug development targets. 
  • Bioanalysis in Clinical Research: Bioanalysis is the sub-discipline of analytical chemistry that deals with the qualitative & quantitative measurement of small molecules such as drugs, metabolites and, endogenous substances in complex biological samples. Optimization of sample preparation techniques using solid phase extraction and hyphenated chromatographic & electrophoretic techniques is carried out. 
  • Oligonucleotides: Characterization and analysis of synthetic oligonucleotides, with an emphasis on utilizing advanced chromatographic and mass spectrometric techniques. 

Google Scholar

ResearchGate

Publications 

1

Hoda M Marzouk, Amira S Gouda, Mamdouh R Rezk, Ahmed M Abdel-Megied “Innovative eco-friendly stability-indicating HPLC-PDA method for simultaneous determination of the emerging antiviral drugs against COVID-19 infection molnupiravir and favipiravir; degradation kinetic studies along with LC-MS based structure elucidation” Microchemical J. 2024; 205, 111197. https://doi.org/10.1016/j.microc.2024.111197 (Q1, IF 5.3).

2

Galal Magdy, Amira A Al-enna, Fathalla Belal, Ramadan A El-Domany, Ahmed M Abdel-Megied “Quality-by-design optimized RP-HPLC approach for the therapeutic drug monitoring of glibenclamide and fluoxetine in human plasma” Microchemical J. 2024; 201, 110548. https://doi.org/10.1016/j.microc.2024.110548 (Q1, IF 5.3).

3

Hoda M Marzouk, Amira S Gouda, Mamdouh R Rezk, Ahmed M Abdel-Megied “A validated LC-MS/MS method for determination of Molnupiravir and Favipiravir in human plasma; Assessment of the remarkable potential synergistic effect against SARS-CoV-2 Infection: Application to a pharmacokinetic study in healthy Egyptian volunteers”. Microchemical J. 2024; 197, 109815. https://doi.org/10.1016/j.microc.2023.109815 (Q1, IF 5.3).

4

 

Rania Elkeeb, Anomeh Avartoomian, Amira S Gouda, Ahmed M Abdel-Megied, Ola Abdallah, Eman Atef “PBPK Evaluation of Sofosbuvir Dose in Pediatrics Using Simcyp®” Sci. Pharm. 2023, 91(3), 38;. https://doi.org/10.3390/scipharm91030038 (Q2, IF: 2.5).

5

Ahmed M. Abdel‑Megied, Isaac A. Monreal, Limian Zhao, Alex Apffel, Hector C. Aguilar, Jace W. Jones “Characterization of the cellular lipid composition during SARS‑CoV‑2 infection” Anal Bioanal Chem. 2023, 415, 5269–5279. https://doi.org/10.1007/s00216-023-04825-1 (Q1, IF: 4.3).

6

Galal Magdy, Amira A Al-Enna, Fathalla Belal, Ramadan A El-Domany, Ahmed M Abdel-Megied “Analytical quality-by-design approach for development and validation of HPLC method for the simultaneous estimation of omarigliptin, metformin, and ezetimibe: application to human plasma and dosage forms” BMC Chemistry. 2023, 17, 45. https://doi.org/10.1186/s13065-023-00955-w (Q2, IF: 4.6).

7

Amira S Gouda, Hoda M Marzouk, Mamdouh R Rezk, Ahmed M Abdel-Megied “Ecofriendly stability-indicating UHPLC-PDA method for determination of the new influenza antiviral prodrug Baloxavir Marboxil; Application to degradation kinetic studies and structure elucidation of the major degradation products using LC-MS” Sust Chem & Pharm. 2023, 33, 101093. https://doi.org/10.1016/j.scp.2023.101093 (Q1, IF: 6.0).

8

A Salem, A Gouda, H Marzouk, M Rezk, A M. Abdel-Megied “A Population Pharmacokinetic Modelling Approach to Evaluate the Current Dosing Recommendations of Favipiravir in Egyptian Subjects” Int J Infect Dis. 2023, 130, S94. https://doi.org/10.1016/j.ijid.2023.04.234 (Q1, IF: 12.0).

9

Ahmed M Abdel‐Megied, Sergiy Kovalenko, Fawzy A Elbarbry, Marjan Piponski, Oleksandra Oleshchuk, Sami El Deeb, Galal Magdy, Fathalla Belal, Taras Grochovuy, Liliya Logoyda “LC‐MS/MS Bioanalytical Method for the Quantitative Analysis of Nifedipine, Bisoprolol, and Captopril in Human Plasma: Application to Pharmacokinetic Studies”. J Biomed Chromatogr. 2023; Online Record: e5664. https://doi.org/10.1002/bmc.5664 (Q2, IF: 1.8).

10

Amira S Gouda, Ahmed M Abdel-Megied, Mamdouh R Rezk, Hoda M Marzouk “LC-MS/MS-based metabolite quantitation of the antiviral prodrug baloxavir marboxil, a new therapy for acute uncomplicated influenza, in human plasma: Application to a human pharmacokinetic study” J Pharm Biomed Anal. 2023, 20, 115165. https://doi.org/10.1016/j.jpba.2022.115165 (Q2, IF: 3.4)

Professional Affiliations & Memberships 

  • American Association of College of Pharmacy (AACP) 
  • Royal Society of Chemistry (RSC)  
  • American Society of Mass Spectrometry (ASMS)  
  • American Association of Pharmaceutical Scientists (AAPS)

 

 

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